Ohio State vs. Indiana Prediction Odds: College Football Week 11 Picks 2022 Best Bets From Computer Model

The second-ranked Ohio State Buckeyes look to win their 27th straight game over the Indiana Hoosiers when they meet in a key Big Ten Conference East Division matchup on Saturday. The Buckeyes (9-0, 6-0), one of four remaining undefeated teams, are coming off a 21-7 win at Northwestern last week. The Hoosiers (3-6, 1-5), who have lost 13 straight in October and November, are coming off a 45-14 loss to Penn State. This will be the first time Indiana has been a 40-point underdog since 1995.

Kickoff from Ohio Stadium in Columbus, Ohio is set for noon ET. Ohio State is averaging 45.8 points per game this season, best in the nation, while Indiana is averaging 23.3, 11th best in the Big Ten and 100th in the nation. The Buckeyes are favored by 40 points in the latest Indiana vs. Ohio State from Caesars Sportsbook, while the over-under for total points scored is 61. Before making any Ohio State vs. Indiana picks, you should check out the college football predictions and betting tips from SportsLine’s advanced computer model.

The SportsLine projection model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a staggering profit of nearly $3,000 for $100 players on college football’s top picks against the spread. Anyone who has followed it has seen tremendous returns.

Now, the model has Ohio State vs. Indiana in its sights and has locked in its picks and CFB projections. You can head over to SportsLine now to check out the model options. Here are several college football odds and betting lines for Indiana vs. Ohio State:

  • Ohio State vs. Indiana spread: Ohio State -40
  • Ohio State vs. Indiana over/under: 61 points
  • IU: Hoosiers are 6-1 against the spread in their last seven games after giving up more than 40 points in their previous game
  • OSU: The Buckeyes are 3-0-1 ATS in their last four home games
  • Ohio State vs. Indiana picks: See the picks at SportsLine

Because Ohio State can cover

Junior running back Miyan Williams leads the Buckeyes in rushing, carrying 102 times for 636 yards (6.2 avg.) and 12 touchdowns this season. He has rushed for 100 or more yards in three of the last five games, including 111 yards on 26 carries (4.3 avg.) and two touchdowns in last week’s win at Northwestern. He also carried 21 times for 189 yards (9.0 avg.) and five TDs in a 49-10 win over Rutgers on Oct. 1. 9.2 average) and two ratings.

The Buckeyes haven’t allowed Indiana a rushing touchdown or 100 yards rushing in a game in six years. Helping out on defense is senior linebacker Tommy Eichenberg, who leads the team with 85 tackles, including 53 solo. He also has 2.5 sacks for 12 yards, two pass breakups and an interception and returned a fumble 15 yards for a touchdown. Eichenberg is coming off back-to-back games in which he posted double-digit tackles with 28 total at Northwestern and Penn State, including 10 solo tackles in each game.

Because Indiana can cover

Still, the Buckeyes aren’t a lock to cover the spread between Indiana and Ohio State. That’s because the Hoosiers have played Ohio State tough over the past decade, including three one-score games. After missing last week’s game with an injury, junior quarterback Connor Bazelak will return. For the season, he has completed 208 of 379 passes (54.9%) for 2,099 yards and 12 touchdowns with nine interceptions. He also rushed for a score.

His top target was wide receiver Cam Camper, but the junior will miss the rest of the season with a torn ACL. One of those players who will need to step up is senior Emery Simmons, who is second on the team with 32 receptions for 335 yards (10.5 avg.) and one touchdown. His best game so far this season was a six-and-99-yard performance against Maryland in a 38-33 loss on Oct. 15. He also caught six passes for 57 yards (9.5 avg.) and a touchdown in a 35-21 loss at Nebraska on Oct. 1.

How to make Indiana vs. Ohio State picks

SportsLine’s model leans on the whole, projecting a total of 65 points. The model also says that one side of the spread hits in almost 60% of the simulations. You can see the model’s CFB options only at SportsLine.

So who wins Ohio State vs. Indiana? And which side of the spread hits in almost 60% of the simulations? Visit SportsLine now to see which side of the spread to jump on, all from the model who crushed his college football picks and find out.

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